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Expanding precision medicine to the rest of the genome

BreakSight, Inc. is a biotech company focused on enabling the discovery of novel DNA sequence markers with the potential to predict response to targeted cancer therapies.

Our technology is based on identifying DNA break signatures associated with DNA damage-inducing therapeutics and aims to impact precision medicine by expanding the range and use of actionable DNA biomarkers with therapeutic potential.

Home: Welcome

Discover the unseen. Locating DNA breaks with precision.

Our Work

Guiding Principles

How it Works

Working with Pharma

Our Services

Our Products

Closeup of a Petri Dish


  • Tag and retrieve DNA double-strand break sites across the genome from cells that have acquired DNA damage

  • Conduct next-generation sequencing (NGS) on captured DNA break fragments 

  • Includes library prep, QC, and 150 bp paired-end sequencing

  • Ideal for proliferating cell cultures acutely exposed to DNA damaging treatments or conditions

  • 20% off of your first 4 samples!

Add RNA-Seq analysis

  • Ask about adding RNA-Seq analysis alongside DDsite

  • Learn more about activated or repressed pathways in cells exposed to your DNA-damaging conditions

Scientist on Computer


  • Analyze sequenced data through our stringent analysis pipeline to pinpoint reproducible sites of DNA breakage across the genome, specific to your treatment conditions​

  • Compare break sites across treatment conditions


Request DDinsight+​​​​​


  • ​Uncover DNA repeats and sequence motifs enriched at DNA break regions

  • ​​Associate identified DNA break sites with publicly available databases of genome-wide elements (e.g. ChIP-Seq data, gene regions, histone marks, etc.)​


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