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Expanding precision medicine to the rest of the genome

BreakSight, Inc. is a biotech company focused on enabling the discovery of novel DNA sequence markers with the potential to predict response to targeted cancer therapies.

Our technology is based on identifying DNA break signatures associated with DNA damage-inducing therapeutics and aims to impact precision medicine by expanding the range and use of actionable DNA biomarkers with therapeutic potential.

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Discover the unseen. Locating DNA breaks with precision.

Our Work

Guiding Principles

How it Works

Working with Pharma

Our Services

Our Products

Closeup of a Petri Dish


  • Tag and retrieve DNA double-strand break sites across the genome from cells that acquire DNA damage during proliferation

  • Ideal for cell cultures exposed to DNA damaging treatments or conditions for an acute time

  • Performance of next-generation sequencing (NGS) by an NGS provider on the captured DNA break fragments 

  • Includes library prep, QC, and 150 bp paired-end sequencing

  • 20% off of your first 4 samples!

Scientist on Computer


  • Analyze sequenced data through our stringent analysis pipeline to pinpoint reproducible sites of DNA breakage across the genome, specific to customer treatment conditions​

  • Compare break sites across treatment conditions

Upon request for DDinsight+...​​


  • Uncover DNA repeats and sequence motifs enriched at DNA break regions

  • ​​Associate identified DNA break sites with publicly available databases of genome-wide elements (e.g. ChIP-Seq data, gene regions, histone marks, etc.)


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