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Expanding precision medicine to the rest of the genome

BreakSight, Inc. is a biotech company focused on enabling the discovery of novel DNA sequence markers with the potential to predict response to targeted cancer therapies.

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Our technology is based on identifying DNA break signatures associated with DNA damage-inducing therapeutics and aims to impact precision medicine by expanding the range and use of actionable DNA biomarkers with therapeutic potential.

Home: Welcome

Discover the unseen. Locating DNA breaks with precision.

Our Work

Guiding Principles

How it Works

Working with Pharma

Our Services

Our Products

Closeup of a Petri Dish

DDsite

  • Tag and retrieve DNA double-strand break sites across the genome from cells that have acquired DNA damage​

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  • Conduct next-generation sequencing (NGS) on captured DNA break fragments 

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  • Includes library prep, QC, and 150 bp paired-end sequencing​

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  • Ideal for proliferating cell cultures acutely exposed to DNA damaging treatments or conditions

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  • 20% off of your first 4 samples!

Add RNA-Seq analysis​

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  • Ask about adding RNA-Seq analysis alongside DDsite

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  • Learn more about activated or repressed pathways in cells exposed to your DNA-damaging conditions

Scientist on Computer

DDinsight

  • Analyze sequenced data through our stringent analysis pipeline to pinpoint reproducible sites of DNA breakage across the genome, specific to your treatment conditions​

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  • Compare break sites across treatment conditions

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Request DDinsight+​​​​​

 

  • ​Uncover DNA repeats and sequence motifs enriched at DNA break regions

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  • ​​Associate identified DNA break sites with publicly available databases of genome-wide elements (e.g. ChIP-Seq data, gene regions, histone marks, etc.)​

     

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